What is the consequence of developing substance tolerance?

Developing substance tolerance refers to the body's adaptation to the presence of a substance, leading to a change in its response. As tolerance builds, the individual typically finds that they need to consume larger amounts of the substance to achieve the same desired effect that they previously experienced at lower doses. This increase in the quantity required is due to physiological changes in the body’s receptors or metabolic processes, which diminish the initial response over time.

The other options do not accurately reflect the nature of substance tolerance. Smaller amounts for the same effect contradict the definition of tolerance. Heightened pleasure is not a direct consequence of tolerance; instead, users may find that the pleasure diminishes as it becomes more challenging to achieve previous highs. Increased anxiety is typically associated with withdrawal or other effects surrounding substance use rather than being a direct result of tolerance itself.